Central Michigan at Michigan---CMU showed well in last week's near-comeback against Boston College. Michigan's at home and is just too good, however. After the energy of last weekend's game I expect a modest letdown by CMU and an easy win for Michigan.
Penn State at Notre Dame---The Nittany Lions are going to have to fight like hell to hold the Irish under 30 after a disappointing start last weekend. The Irish return home and should look to assert themselves on both sides of the ball. I see an easy Irish win here.
Washington at Oklahoma---Twenty years ago this would have been an amazing game. Now... not so much. The Huskies should be game offensively but in the end Oklahoma prevails. Expect a better outing from Paul Thompson, perhaps on the ground.
Clemson at Boston College---The Eagles had a somewhat disappointing start against Central Michigan, steadily building a big lead before hemorrhaging points late. With perhaps the best offense in school history, I expect Clemson to roar through the majority of its ACC slate and today's game is a win they need to have to live up to expectation. I like Clemson here.
Colorado at Colorado State---To be honest I have no idea what to expect here. Colorado has more talent, but what to make of that I-AA loss last weekend? Stanford was able to recover reasonably well from its I-AA loss last year, so count on a Buffalo rebound sooner rather than later. That said, Colorado State smells blood here and looks to claim their first decisive victory in this series in a while.
Arizona at LSU---This might be a better Pac-10 performance against the SEC given the low national expectations for the Wildcats. That said, the Wildcats don't have much of an offense or run game and don't really expect to win this game. LSU big.
Minnesota at California---The Golden Bears badly need a rebound victory to put the Tennessee performance behind them. They have more than enough talent here and should win with the ground game.
Georgia at South Carolina---The Gamecocks should have a nice homefield advantage here. Both offenses looked sad in their openers and should have a better showing this time out. With great hesitation, I like South Carolina here. They have a little more balanced, competent offense and the crazies cheering them on. This should be a very tight game.
Ohio State at Texas---I could see this game going both ways. Ohio State's defense may be leaky enough for Texas to relax at some point in the game and start scoring some points. The home setting should also help the Longhorns. I actually feel Colt McCoy will have a quality outing, but Ohio State should find its way to just enough points for victory here and make just enough defensive stops, particularly early in the game.
Texas Tech at UTEP---Jordan Palmer was an interception machine last weekend for UTEP, letting San Diego State hang close. That just won't do against Mike Leach's Red Raiders. This should be a wild one, but Texas Tech has the edge and should win by two touchdowns.
Oregon at Fresno State---This is allegedly the biggest game ever played IN Fresno. Call it suicidal, call it whatever, Oregon's got some stones for playing here. They snuck by Fresno State at home last year, and this game should be equally tight, especially with an injury to star back Johnathan Stewart. Having a new starter at quarterback will hold the Bulldogs up just enough to let Oregon escape, however.